It was very annoying. Ajax request not works perfectly in IE. But when developer tool is opened ajax quires are works fine. It was very cumbersome . It happened because IE chache Ajax requests. When Developer tool opened it is always refresh from server.

I get this fixed by making cache false in ajax request.

$.ajax({
type: "GET",
url: url,
dataType: "html",
contentType: "application/json; charset=utf-8",
data: JSON.stringify({}),
cache: false,
success: function (r) {
}
});

I think it might help you.